:root{color-scheme:light;--bg:#fafaf8;--panel:#fff;--line:#e2e2dc;--text:#151715;--muted:#7b7d75;--mint:#244e3c;--shadow:0 2px 3px #18281805}*{box-sizing:border-box}body{margin:0;background:var(--bg);color:var(--text);font:14px/1.55 -apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif}button,input,select{font:inherit}button,input,select,a{-webkit-tap-highlight-color:transparent}button{color:inherit;cursor:pointer;background:#fff;border:1px solid var(--line);border-radius:10px;padding:9px 14px;transition:background .18s,border-color .18s,box-shadow .18s}button:hover{background:#f3f5f1;border-color:#bcc9bd}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible{outline:2px solid var(--mint);outline-offset:4px}a{color:inherit}header{height:80px;border-bottom:1px solid var(--line);padding:0 max(3.2vw,24px);display:flex;align-items:center;justify-content:space-between;gap:24px}.brand{display:flex;align-items:center;gap:12px;text-decoration:none;font-size:22px;font-weight:600;letter-spacing:-.8px}.brand-icon{display:grid;place-items:center;width:35px;height:35px;background:#141614;color:white;border:1px solid #000;border-radius:8px;font-size:24px;line-height:1}.brand-sub{font-size:11px;font-weight:400;letter-spacing:.6px;background:#efefea;padding:4px 10px;border-radius:5px;margin-left:20px;position:relative}.brand-sub:before{content:"";height:20px;width:1px;background:var(--line);position:absolute;left:-15px;top:3px}.header-actions{display:flex;align-items:center;gap:24px}#about{border:0;background:transparent;padding:6px 0;font-size:13px}.snapshot-chip{display:flex;align-items:center;gap:9px;background:#f1f1ed;border:1px solid #e7e7e1;border-radius:24px;font-size:12px;padding:6px 13px;white-space:nowrap}.snapshot-chip i{width:6px;height:6px;border-radius:50%;background:#1bb683}main{max-width:1700px;padding:48px max(3.2vw,24px) 0;margin:auto}.intro{display:flex;align-items:flex-end;justify-content:space-between;gap:30px;border-bottom:1px solid var(--line);padding-bottom:40px;margin-bottom:42px}.eyebrow{font-size:11px;letter-spacing:.8px;font-weight:500;color:var(--muted);margin:0 0 12px}.intro .eyebrow span{color:var(--mint)}.intro .eyebrow b{font-size:17px;color:#b6b7ae;margin:0 12px;font-weight:400}h1{font-size:clamp(35px,3.5vw,54px);font-weight:400;letter-spacing:-1.8px;line-height:1.2;margin:16px 0 19px}h1 em{font-family:Georgia,serif;color:var(--mint);font-weight:400;border-bottom:1px solid #b5c6b8}.intro p:not(.eyebrow){font-size:17px;color:#44483f;line-height:1.6;margin:0}.snapshot{display:flex;align-items:center;gap:15px;flex-shrink:0;background:#fff;border:1px solid var(--line);box-shadow:var(--shadow);border-radius:15px;padding:14px 22px;font-size:11px;letter-spacing:.8px;color:var(--muted);min-width:280px}.snapshot small{display:block;font-size:13px;font-weight:550;letter-spacing:0;color:var(--text);margin-top:1px}.live-dot{display:block;width:9px;height:9px;border-radius:50%;background:#426b58}.toolbar{display:flex;align-items:center;gap:16px;margin-bottom:32px}.search{flex:1;min-width:0;border:1px solid var(--line);background:#fff;border-radius:14px;padding:10px 16px;display:flex;align-items:center;gap:12px;box-shadow:var(--shadow);height:52px}.search span{font-size:25px;line-height:1;color:var(--muted)}input[type=search]{border:0;background:transparent;color:var(--text);font-size:15px;width:100%;min-width:0;padding:4px 0}input::placeholder{color:#81847b}.view-toggle{display:flex;align-items:center;padding:5px;border:1px solid var(--line);border-radius:14px;background:white;box-shadow:var(--shadow);white-space:nowrap}.view-toggle button{border:0;padding:7px 16px;background:transparent;border-radius:9px;font-size:13px}.view-toggle [aria-pressed=true]{background:#151715;color:#fff;box-shadow:0 1px 2px #0002}#toggle-filters{white-space:nowrap;font-size:13px;box-shadow:var(--shadow);padding:11px 16px}#toggle-filters span{margin-right:7px}#toggle-filters[aria-expanded=true]{background:#eaf1eb;border-color:#b6c7b8}.layout{display:grid;grid-template-columns:clamp(255px,23%,345px) minmax(0,1fr);gap:36px;align-items:start}.navigation{background:#fff;border:1px solid var(--line);border-radius:19px;padding:24px;box-shadow:var(--shadow)}.nav-heading{display:flex;align-items:center;justify-content:space-between;gap:10px;border-bottom:1px solid #edede7;padding-bottom:15px;margin-bottom:14px}.nav-heading .eyebrow{font-size:12px;margin:0;letter-spacing:.65px}.nav-heading>span{font-size:11px;white-space:nowrap;color:var(--muted)}.navigation nav{display:grid;gap:4px}.category{display:flex;align-items:center;gap:12px;width:100%;text-align:left;border-color:transparent;padding:11px 13px;border-radius:10px;font-size:13px}.dot{width:9px;height:9px;border-radius:50%;flex-shrink:0}.count{margin-left:auto;font-size:11px;color:#85877e;font-variant-numeric:tabular-nums}.category[aria-pressed=true]{background:#f2f7f3;border-color:#e2ebe3;color:var(--mint)}.category[aria-pressed=true] .count{background:#e7f0e9;color:#3b6049;padding:3px 7px;border-radius:5px}.nav-note{border-top:1px solid #edede7;padding-top:20px;margin:20px 0 26px;color:var(--muted);font-size:11px;line-height:1.7}.navigation>label{display:block;margin:0 0 8px}.navigation>select{width:100%}.navigation>button{display:block;width:100%;text-align:left;margin-top:18px;background:#f6f6f3;font-size:13px;padding:12px}#saved-count{float:right;border:1px solid var(--line);background:#fff;border-radius:20px;padding:0 6px;font-size:10px}#saved[aria-pressed=true]{background:#eaf1eb;border-color:#b6c7b8}#reset{font-size:11px;background:transparent;color:var(--muted);border:0;text-align:center;margin-top:6px;padding:5px}.content{min-width:0}.sync-note{color:var(--muted);font-size:10px;margin:-18px 0 14px}.view-description{font-size:11px;color:var(--muted);line-height:1.7;margin:0 0 18px}.map-panel{background:#fff;border:1px solid var(--line);border-radius:19px;box-shadow:var(--shadow);padding:30px;overflow:visible}.map-top{display:flex;align-items:center;justify-content:space-between;gap:20px;padding-bottom:25px;border-bottom:1px solid #edede7;margin-bottom:28px}.map-top .eyebrow{margin-bottom:6px;font-size:11px}.map-top h2{font-size:22px;letter-spacing:-.5px;line-height:1.4;font-weight:450;margin:0}.map-top button{font-size:12px;white-space:nowrap;padding:8px 13px;color:#454b41}.connected-cards{display:grid;grid-template-columns:1fr 1fr;gap:32px 36px}.treatment-group{min-width:0;padding-bottom:30px;border-bottom:1px solid #edede7}.group-heading{display:flex;align-items:center;justify-content:space-between;gap:8px;margin-bottom:17px}.group-heading h3{font-size:14px;font-weight:500;margin:0;display:flex;align-items:center;gap:10px}.group-heading h3:before{content:"";display:block;width:9px;height:9px;background:var(--group-accent);border-radius:50%;flex-shrink:0}.group-heading button{white-space:nowrap;border:0;background:transparent;padding:0;font-size:12px}.floating-cards{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:14px;padding:4px 0}.floating-card{display:flex;flex-direction:column;position:relative;text-align:left;border:1px solid var(--line);border-radius:15px;background:#fafaf8;min-height:202px;padding:16px;scale:1;transform-origin:center;transition:scale 180ms ease,box-shadow 180ms ease,border-color 180ms ease;animation:card-drift 4s ease-in-out var(--card-delay) infinite alternate}.floating-card:hover{background:#fff;border-color:#b7c7ba}.mini-meta{display:flex;justify-content:space-between;gap:5px;color:#85887e;font-size:11px}.mini-meta>span{color:#a6a99f}.floating-card strong{font-size:13px;font-weight:450;line-height:1.45;margin:13px 0 18px;color:#151715;display:-webkit-box;-webkit-line-clamp:4;-webkit-box-orient:vertical;overflow:hidden;overflow-wrap:anywhere}.mini-type{margin-top:auto;font-size:10px;line-height:1.5;border:1px solid transparent;border-radius:4px;padding:5px 8px;align-self:flex-start;background:#efefeb;color:#444940}.floating-card:after{content:"";order:0} .paused .floating-card{animation-play-state:paused!important}@keyframes card-drift{from{transform:translateY(-4px)}to{transform:translateY(4px)}}.map-panel .floating-card:focus-visible{scale:1.18;z-index:5;animation-play-state:paused!important;box-shadow:0 14px 30px #293a2920}@media(hover:hover) and (pointer:fine){.map-panel .floating-card:hover{scale:1.18;z-index:5;animation-play-state:paused!important;box-shadow:0 14px 30px #293a2920}}.map-bottom{display:flex;align-items:center;justify-content:space-between;gap:20px;padding-top:24px;font-size:11px;color:var(--muted)}.map-bottom>div{display:grid;gap:4px}.map-bottom button{border:0;background:transparent;color:var(--mint);padding:5px 0;font-size:12px;text-align:right}.results-head{display:flex;align-items:center;justify-content:space-between;gap:15px;margin:35px 0 20px}.results-head h2{font-size:23px;font-weight:450;letter-spacing:-.5px;line-height:1.4;margin:0}.results-head .eyebrow{font-size:10px;margin-bottom:5px}.filter-panel{margin:-16px 0 32px;padding:20px 24px;border:1px solid var(--line);border-radius:14px;background:#fff;display:flex;align-items:center;gap:22px;flex-wrap:wrap;box-shadow:var(--shadow)}select{border:1px solid var(--line);border-radius:9px;background:#f6f6f2;color:#30382e;padding:10px 12px;font-size:12px;max-width:100%}.sort-label{font-size:12px;display:flex;align-items:center;gap:9px;white-space:nowrap}.refinements{display:flex;gap:20px;align-items:center;flex-wrap:wrap;font-size:12px}.refinements input{accent-color:var(--mint);margin-right:6px;vertical-align:middle}.design-label{display:flex;align-items:center;gap:9px}.results{display:grid;grid-template-columns:1fr 1fr;gap:16px}.study-card{display:flex;flex-direction:column;align-items:stretch;text-align:left;padding:24px;border:1px solid var(--line);border-radius:15px;background:#fff;min-height:205px;box-shadow:var(--shadow)}.study-card:hover{background:#fafbf8;border-color:#bdccbf}.card-meta{display:flex;justify-content:space-between;gap:12px;font-size:10px;color:var(--muted);letter-spacing:.5px}.study-card h3{font-size:15px;font-weight:450;line-height:1.55;margin:14px 0 22px}.card-bottom{margin-top:auto;display:flex;align-items:center;gap:8px;flex-wrap:wrap}.pill{display:inline-block;border:1px solid var(--line);border-radius:5px;background:#f1f2ed;color:#56614e;padding:4px 8px;font-size:10px;line-height:1.5}.study-badges{display:flex;align-items:center;gap:6px;flex-wrap:wrap}.availability-badge{display:inline-flex;border-radius:5px;border:1px solid;padding:4px 8px;font-size:10px;line-height:1.5;font-weight:500}.appraisal-badge{background:#eaf5ec;border-color:#c7e3ce;color:#29623e}.fulltext-badge{background:#edf5fd;border-color:#cadeef;color:#285e87}.no-appraisal{font-size:10px;color:var(--muted)}.arrow{margin-left:auto;font-size:18px;color:var(--mint)}.type-review,.type-guideline{background:#f0fcf8;color:#007569;border-color:#c2ece3}.type-trial{background:#fff9eb;color:#945c00;border-color:#f0dbad}.type-case{background:#f4f2ff;color:#5144b1;border-color:#ddd8fc}.type-discussion,.type-letter{background:#f2f1ed;color:#55574f;border-color:#e4e3db}.type-observational,.type-diagnostic{background:#eff7ff;color:#23618c;border-color:#d3e8fa}#more{display:block;margin:25px auto;color:var(--mint);background:#fff;padding:10px 22px}footer{border-top:1px solid var(--line);display:flex;justify-content:space-between;gap:25px;padding:28px 0;margin-top:70px;color:var(--muted);font-size:11px}#footer-snapshot{max-width:50%}.active-filters{background:#f2f6f1;border:1px solid #dce7dc;border-radius:13px;padding:13px 16px;margin:0 0 20px}.filter-bar{display:flex;align-items:center;justify-content:space-between;gap:12px;font-size:11px;color:#596c53;margin-bottom:9px}.filter-bar button{padding:4px 9px;font-size:11px;white-space:nowrap}.filter-badges{display:flex;flex-wrap:wrap;gap:7px}.filter-badge{display:flex;align-items:center;gap:12px;border-radius:20px;background:#fff;font-size:11px;padding:5px 11px;max-width:100%;overflow-wrap:anywhere;text-align:left}.filter-badge span{font-size:16px;flex-shrink:0;line-height:1}dialog{background:#fff;color:var(--text);border:1px solid var(--line);border-radius:20px;padding:30px 36px;max-width:760px;width:calc(100% - 32px);max-height:90vh;line-height:1.85;box-shadow:0 24px 90px #203b3826}dialog::backdrop{background:#29342b55;backdrop-filter:blur(6px)}.dialog-bar{display:flex;align-items:center;justify-content:space-between;gap:20px;margin-bottom:24px}.dialog-bar button{border:0;font-size:25px;padding:0 8px}.dialog-bar .eyebrow{margin:0}dialog h2{font-size:28px;font-weight:450;letter-spacing:-.6px;line-height:1.4;margin:0 0 20px}dialog h3{font-size:13px;font-weight:600;margin:24px 0 9px}dialog p{font-size:13px;color:#586351}.study-tags{display:flex;gap:6px;flex-wrap:wrap;margin:14px 0}.study-actions{display:flex;gap:9px;flex-wrap:wrap;margin:20px 0}.study-actions a{border-radius:8px;border:1px solid #c9d9c8;background:#eff6ee;color:var(--mint);text-decoration:none;padding:9px 13px;font-size:12px}.study-actions button{font-size:12px}.provenance,.publication-note{border:1px solid #dde6d9;border-radius:10px;padding:13px 16px;background:#f7f9f5;font-size:11px;color:#65735d;margin:20px 0}.publication-note p{font-size:11px;margin:7px 0 0}.publication-note .pill{font-size:11px}.source-text{white-space:pre-wrap;overflow-wrap:anywhere;font-size:12px;line-height:1.9;color:#4d5c46}.study-section{border-top:1px solid var(--line);padding:2px 0 14px}details{margin-top:20px;border-top:1px solid var(--line);padding-top:15px}summary{cursor:pointer;font-size:13px;color:var(--mint)}.related{display:grid;gap:8px}.related button{text-align:left;font-size:12px}.empty{text-align:center;padding:40px;grid-column:1/-1;color:var(--muted)}.empty h3{font-weight:450;color:var(--text)}.sr-only,.skip:not(:focus){position:absolute;width:1px;height:1px;overflow:hidden;clip-path:inset(50%)}.skip:focus{position:fixed;z-index:10;background:var(--mint);color:white;padding:12px}[hidden]{display:none!important}#study{transform-origin:center}#study[open]::backdrop{animation:study-backdrop-in 360ms ease-out}@keyframes study-backdrop-in{from{background:#29342b00;backdrop-filter:blur(0)}to{background:#29342b55;backdrop-filter:blur(6px)}}@media(prefers-reduced-motion:reduce){*{animation:none!important;transition:none!important}}
@media(max-width:1250px){.layout{grid-template-columns:255px minmax(0,1fr);gap:26px}.connected-cards{grid-template-columns:1fr}.floating-card{min-height:188px}.map-top h2{font-size:20px}.map-panel{padding:25px}.results{grid-template-columns:1fr}.snapshot{min-width:240px;padding:13px 18px}.intro p:not(.eyebrow){font-size:15px}.navigation{padding:20px}.category{padding:10px 9px;font-size:12px}.brand-sub{font-size:10px}.header-actions{gap:18px}}
@media(max-width:850px){.snapshot{display:none}.brand-sub{display:none}.toolbar{gap:10px;flex-wrap:wrap}.search{flex-basis:60%}.view-toggle{margin-left:auto}.layout{grid-template-columns:215px minmax(0,1fr);gap:18px}.navigation{padding:16px}.nav-heading>span{display:none}.category{font-size:11px;gap:8px}.map-panel{padding:20px}.map-top{align-items:start;flex-wrap:wrap;gap:14px}.map-top h2{font-size:19px}.floating-cards{gap:10px}.floating-card{padding:12px;min-height:185px}.floating-card strong{font-size:12px}.mini-meta{font-size:10px}.mini-type{font-size:9px;padding:4px 6px}.map-bottom{display:block}.map-bottom button{margin-top:12px}.nav-heading .eyebrow{font-size:10px}.intro{margin-bottom:30px;padding-bottom:30px}.filter-panel{margin-top:-12px;gap:16px}.refinements{gap:14px}}
@media(max-width:650px){header{height:68px;padding:0 20px;gap:12px}.brand{font-size:19px}.brand-icon{width:30px;height:30px;font-size:21px}.header-actions{gap:8px}.snapshot-chip{display:none}#about{font-size:11px}main{padding:30px 20px 0}.intro{padding-bottom:26px;margin-bottom:25px}.intro .eyebrow{font-size:8px;letter-spacing:.6px}.intro .eyebrow b{margin:0 6px;font-size:12px}h1{font-size:36px;letter-spacing:-1.3px;margin-top:12px}.intro p:not(.eyebrow){font-size:13px}.toolbar{margin-bottom:28px;gap:10px}.search{flex-basis:100%;height:48px;padding:8px 13px}.search input{font-size:13px}.view-toggle{margin-left:0}.view-toggle button{font-size:12px;padding:6px 13px}#toggle-filters{margin-left:auto;font-size:12px;padding:10px 13px}.layout{display:flex;flex-direction:column;gap:25px}.navigation{width:100%;border-radius:14px;padding:15px}.nav-heading{border:0;padding:0;margin:0 0 11px}.nav-heading .eyebrow{font-size:10px}.nav-heading>span{display:block}.navigation nav{display:flex;overflow:auto;gap:5px;padding:3px 3px 10px}.category{width:auto;white-space:nowrap;border-color:var(--line);flex-shrink:0;font-size:11px;padding:7px 10px;gap:8px}.category .count{margin-left:3px}.nav-note{display:none}.navigation>label{font-size:9px;margin-top:10px}.navigation>select{width:100%;font-size:12px}.navigation>button{display:inline-block;width:auto;font-size:11px;margin:12px 5px 0 0;padding:8px 11px}#saved-count{margin-left:8px}#reset{padding:8px} .content{width:100%}.sync-note{font-size:10px;margin:0 0 12px;line-height:1.7}.view-description{font-size:10px}.map-panel{padding:18px 16px;border-radius:15px}.map-top{margin-bottom:22px;padding-bottom:20px}.map-top .eyebrow{font-size:9px}.map-top h2{font-size:18px}.map-top button{font-size:10px;padding:7px 10px}.connected-cards{gap:24px}.group-heading h3{font-size:12px;gap:7px}.group-heading button{font-size:10px}.floating-cards{gap:8px;padding:5px 0}.floating-card{padding:11px 9px;border-radius:11px;min-height:180px}.floating-card strong{font-size:11px;-webkit-line-clamp:5}.mini-meta{font-size:8px}.mini-type{font-size:8px;padding:4px 5px}.treatment-group{padding-bottom:23px}.map-bottom{font-size:10px}.map-bottom button{font-size:11px}.filter-panel{padding:15px;gap:14px}.sort-label{font-size:11px}.refinements{font-size:11px;gap:12px}.design-label{width:100%;flex-wrap:wrap}.design-label select{max-width:100%}.results-head{margin-top:28px}.results-head h2{font-size:21px}.study-card{padding:20px;min-height:185px}.study-card h3{font-size:14px}.card-meta{font-size:9px}.filter-bar{font-size:10px}.filter-badge{font-size:10px}.filter-bar button{font-size:10px}footer{display:block;margin-top:40px;padding:22px 0;font-size:10px}footer span{display:block;margin:7px 0}#footer-snapshot{max-width:none}dialog{padding:22px;border-radius:16px}dialog h2{font-size:23px}.empty{padding:30px 10px}}

.context-line{display:flex;justify-content:space-between;gap:12px 24px;flex-wrap:wrap;margin:-16px 0 25px}.context-line .sync-note,.context-line .view-description{margin:0;font-size:10px}.mini-footer{display:block;margin-top:auto;border-top:1px solid #e8e8e2;padding-top:10px}.mini-type{display:inline-block;margin:0}.floating-card:after{content:none}@media(max-width:650px){.context-line{margin:-12px 0 20px;gap:6px}.context-line .view-description{font-size:10px}.mini-footer{padding-top:8px}}